Esch-sur-Alzette railway station (, , ) is a railway station serving Esch-sur-Alzette, in south-western Luxembourg. It is operated by Chemins de Fer Luxembourgeois (CFL), the state-owned railway company. CFL general refer to the station as Esch/Alzette as shown on the sign.
The station is situated on Line 60, which connects Luxembourg City to the Red Lands of the south of the country. After Esch-sur-Alzette, the main line continues towards Niederkorn, whilst a minor line branches off to Audun-le-Tiche, in France.
As of 2022, it was the third-busiest station in Luxembourg, with over 2.8 million passengers that year.