The Erskine Creek, a perennial stream of the Hawkesbury-Nepean catchment, is located in the Blue Mountains region of New South Wales, Australia.
Formed by the confluence of the Bedford and Glen Erskine creeks, the Erskine Creek (officially designated a river) rises below Mount Erskine, between and , and flows generally south, north-east, and east, before reaching its confluence with the Nepean River, near . The river descends over its course.
The river is entirely contained within the world heritage-listed Blue Mountains National Park.