Epiphyllum thomasianum is an epiphytic species of cactus native to Colombia, Costa Rica, Guatemala, Honduras, Mexico, Nicaragua and Panamá.
The vegetative morphology closely resembles Epiphyllum oxypetalum. The flowers differ due to their striking golden stamina.
Currently two subspecies are recognised: Epiphyllum thomasianum subsp. costaricense and Epiphyllum thomasianum subsp. thomasianum.