Eileen O'Brien

Eileen O'Brien may refer to:

• Eileen O'Brien (actress), English actress
• Eileen O'Brien (journalist) (1925-1986), Irish journalist
• Eileen O'Brien (baseball) (1922–2015), played in the All-American Girls Professional Baseball League in 1946
• Eileen O'Brien, musician, daughter of accordionist Paddy O'Brien