Dominic Edward Murphy (b Balrothery 1651 - d Dublin 1728) was an Irish Roman Catholic bishop in the first third of the 18th century.
Murphy trained in the Irish College at Salamanca and was ordained a priest in Madrid, in 1677. He was consecrated Bishop of Kildare and Leighlin in 1715 and translated to the Archbishopric of Dublin in 1724. He died in post on 22 December 1728.