East Russell Street Area Historic District is a national historic district located at Orangeburg, Orangeburg County, South Carolina. The district encompasses 55 contributing buildings in a residential section of Orangeburg. They include residences constructed between about 1850 and 1930, and includes large, one- and two-story, frame and brick houses and smaller one-story homes occupied by servants. The houses are in a variety of popular architectural styles including Victorian, Colonial Revival, and Bungalow.
It was added to the National Register of Historic Places in 1985.