The East Branch Pleasant River is a tributary of the Piscataquis River in Piscataquis County, Maine. From its source () in Shawtown (Township A, Range 12, WELS), the river runs about generally southeast to Upper Ebeemee Lake, then about south through Ebeemee Lake to its confluence with the West Branch to form the Pleasant River in Brownville.
The Appalachian Trail crosses the East Branch in T.A R.11 WELS ().