Eagle Creek is a long third-order tributary to the Niobrara River in Holt County, Nebraska.
Eagle Creek begins at the confluence of Middle and East Branches of Eagle Creek about southeast of School No. 33 in Holt County and then flows generally northeast to join the Niobrara River about east of Paddock, Nebraska.
Eagle Creek drains of area, receives about of precipitation, and is about 3.13% forested.