Malonyl CoA reductase (malonate semialdehyde-forming) (, NADP-dependent malonyl CoA reductase, malonyl CoA reductase (NADP)) is an enzyme with systematic name malonate semialdehyde:NADP<sup>+</sup> oxidoreductase (malonate semialdehyde-forming). This enzyme catalyse the following chemical reaction
The enzyme requires Mg<sup>2+</sup>. It catalyses the reduction of malonyl-CoA to malonate semialdehyde.