The E. A. Durham House, also known as the Durham-Peters Residence, is a historic home located at Sistersville, Tyler County, West Virginia. It was built in 1921, and is a 20-room Italian Renaissance Revival-style residence. It features pale stone and stucco and a low-pitched green tile roof. The interior features mahogany paneling, a six-foot Carrara marble fireplace, and Dresden chandelier.
It was listed on the National Register of Historic Places in 1973.