The Dupree-Ratliff House is a historic house in Raymond, Mississippi, U.S..
The house was built in 1853 for Dr. H.T.T. Dupree and his wife, Margaret Fairchild. It belonged to the Barksdale family in the 1960s, followed by the Thrashes in the 1980s.
The house was designed in the Greek Revival and Italianate architectural styles. It has been listed on the National Register of Historic Places since July 15, 1986.