Dudhmukhi Wildlife Sanctuary () is a wildlife sanctuary located near Sarankhola in Bagerhat District of Bangladesh. The area of the sanctuary is . It was officially declared as a wildlife sanctuary by the government of Bangladesh on 29 January 2012.
It is one of the safe zones for vultures as per the Vulture Safe Zone-2 Schedule of the government of Bangladesh in 2012. Most of the area of Dudhmukhi consists of wetlands and Dudhmukhi river is one of the dolphin sanctuaries in Bangladesh.