Drillia regia is a species of sea snail, a marine gastropod mollusk in the family Drilliidae.
The database Gastropods.com regards this species as a synonym of Neodrillia enna <small>(W. H. Dall, 1918)</small>, in turn regarded by WoRMS as a synonym of Drillia enna <small>(W. H. Dall, 1918)</small>.
The length of the shell varies between 25 mm and 60 mm.
This species occurs in the Southwestern Pacific Ocean and off the Philippines.