Drillia maculomarginata is a species of sea snail, a marine gastropod mollusc in the family Drilliidae.
The length of the shell of this marine species attains 42 mm, while its width attains 9 mm.
Its whorls are convex and rounded. It is light yellow with splotches of dark brown, and a faint brownish band around the middle of the last whorl. Its protoconch is conical, containing 2 whorls.
This species occurs off the Aliguay Island, the Philippines.