Drake Run is a long 1st order tributary to the Youghiogheny River in Somerset County, Pennsylvania.
According to the Geographic Names Information System, it has also been known historically as:
Drake Run rises about 3 miles north of Draketown, Pennsylvania. The river then flows south to join the Youghiogheny River about 0.75 of a mile northwest of Huston.
Drake Run drains of area and receives about 48.3 in/year of precipitation. Drake Run has a wetness index of 374.92, and is about 92% forested.