The Dr. Nathan Gaither House, at 100 S. High St. in Columbia, Kentucky was listed on the National Register of Historic Places in 1979.
It was a home of Dr. Nathan Gaither (1788âÂÂ1862), who became a doctor and volunteered to receive the smallpox vaccination under development by Edward Jenner. Gaither served as a surgeon in the War of 1812 and settled in Columbia by the end of that war. He served as a doctor and in politics: as an elected member of the Kentucky legislature from 1815 to 1818, and in the United States House of Representatives from 1829 to 1833.