Docosatetraenoylethanolamide (DEA) (Adrenoyl-ethanolamide) (Adrenoyl-EA) is an endogenous ethanolamide that has been shown to act on the cannabinoid (CB<sub>1</sub>) receptor. DEA is similar in structure to anandamide (AEA, a recognized endogenous ligand for the CB<sub>1</sub> receptor), containing docosatetraenoic acid in place of arachidonic acid. While DEA has been shown to bind to the CB<sub>1</sub> receptor with similar potency and efficacy as AEA, its role as a cannabinergic neurotransmitter is not well understood.
Docosatetraenoylethanolamide (DEA) has been found in Tropaeolum tuberosum (Mashua) and Leonotis leonurus (Wild Dagga / Lion's Tail).