Division No. 2 is one of eighteen census divisions in the province of Saskatchewan, Canada, as defined by Statistics Canada. It is located in the south-southeastern part of the province, on the United States border. The most populous community in this division is Weyburn.
In the 2021 Canadian census conducted by Statistics Canada, Division No. 2 had a population of living in of its total private dwellings, a change of from its 2016 population of . With a land area of , it had a population density of in 2021.
The following census subdivisions (municipalities or municipal equivalents) are located within Saskatchewan's Division No. 2.