The Roman Catholic Diocese of Mỹ Tho () is a Roman Catholic diocese in southern Vietnam. The current bishop is Peter Nguyá» n VÃÂn Khảm, former Auxiliary Bishop of the Archdiocese of Ho Chi Minh City. He was appointed by Pope Francis on July 26, 2014, and was installed a month later. His predecessor, Paul Bùi VÃÂn ÃÂá»Âc, was named Coadjutor Archbishop and then Archbishop of the Archdiocese of Ho Chi Minh City, in September, 2013 and in March, 2014, respectively.
The creation of the diocese in its present form was declared on November 24, 1960.
The diocese covers an area of 9,262 km<sup>2</sup> and is a suffragan diocese of the Roman Catholic Archdiocese of Ho Chi Minh City.
By 2021, the diocese of Mỹ Tho had about 138,102 Catholics (3.0% of the population), 148 priests and 113 parishes.
Immaculate Conception Cathedral in Mỹ Tho town has been assigned as the Cathedral of the diocese.