Diacylglycerol cholinephosphotransferase

In enzymology, a diacylglycerol cholinephosphotransferase () is an enzyme that catalyzes the chemical reaction

<div align=center><small>CDP-choline + 1,2-diacylglycerol CMP + a phosphatidylcholine</small></div>

Thus, the two substrates of this enzyme are CDP-choline and 1,2-diacylglycerol, whereas its two products are CMP and phosphatidylcholine.

Classification

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups.

Nomenclature

The systematic name of this enzyme class is CDP choline:1,2-diacylglycerol cholinephosphotransferase. Other names in common use include:

• 1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase,
• 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase,
• 1-alkyl-2-acetylglycerol cholinephosphotransferase,
• alkylacylglycerol choline phosphotransferase,
• alkylacylglycerol cholinephosphotransferase,
• CDP-choline diglyceride phosphotransferase,
• cholinephosphotransferase,
• CPT,
• cytidine diphosphocholine glyceride transferase,
• cytidine diphosphorylcholine diglyceride transferase,
• diacylglycerol choline phosphotransferase,
• phosphocholine diacylglyceroltransferase,
• phosphorylcholine-glyceride transferase, and
• sn-1,2-diacylglycerol cholinephosphotransferase.

Biological role

This enzyme participates in 3 metabolic pathways: aminophosphonate metabolism, glycerophospholipid metabolism, and ether lipid metabolism.

References