Devils Brook is a tributary of the Millstone River in central New Jersey in the United States.
It is a moderately large brook with numerous unnamed tributaries.
The Devils Brook starts at , near exit 8A on the New Jersey Turnpike. It flows west, following Friendship Road. It then passes through the Plainsboro Preserve, feeding a marsh. It joins with Shallow Brook, its tributary, and crosses Scudders Mill Road, also known as CR-614. It crosses Princeton-Plainsboro Road in a dammed section known as Gordon Pond. It then drains into the Millstone River at .
The Devils Brook drains a large area in Mercer and Middlesex counties. There are many tributaries that cross roads, so it is easily accessible.