Desulfomonile is a Gram negative, strictly anaerobic, and non-motile bacterial genus from the phylum Thermodesulfobacteriota. Desulfomonile bacteria can reduce sulfur oxyanions to H<sub>2</sub>S. It is the only known member of the family Desulfomonilaceae, order Desulfomonilales, and class Desulfomonilia.
The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN) and National Center for Biotechnology Information (NCBI).