Desoto Acres is a census-designated place (CDP) in northwestern Sarasota County, Florida, United States. It is north of downtown Sarasota and is bordered to the east by Desoto Lakes.
Desoto Acres was first listed as a CDP prior to the 2020 census. The population was 720 at the 2020 census. It is part of the North Port-Bradenton-Sarasota, Florida Metropolitan Statistical Area.
As of the 2020 census, Desoto Acres had a population of 720 with a total of 296 households. The median household income was $68,986. 30.3% of the population 25 years and older had a bachelor's degree or higher. The CDP had an employment rate of 73.1%. 10.9% of the population lived without healthcare coverage.