Derman Druha () is a village in the Mizoch settlement hromada of the Rivne Raion of Rivne Oblast in Ukraine.
The first written mention of the village was in 1322.
In 1602 a monastery was established in Derman by prince Konstanty Wasyl Ostrogski. Soon thereafter part of the Ostroh printing house was moved to the village, and between 1604 and 1605 a number of religious books were printed there. Between 1625 and 1633 Meletius Smotrytsky served as an archimandrite of the monastery. Later the convent came into possession of Basilian monks. In 1821 Russian authorities transferred it to the Orthodox Church. A seminary functioned in the monastery until 1920, and soon thereafter a girls' school was established, which during the 1930s became a private Ukrainian gymnasium.
On 19 July 2020, as a result of the administrative-territorial reform and liquidation of the Zdolbuniv Raion, the village became part of the Rivne Raion.