Derendorf () is a quarter of Düsseldorf, Germany, part of the central Borough 1. It is located north of Pempelfort and Golzheim, west of Mörsenbroich and south of Unterrath.
Derendorf has an area of , and 20,584 inhabitants (2020).
Derendorf was mentioned as a settlement first time in 1100. In 1384 Derendorf became a part of Düsseldorf. There has been a slaughterhouse in Derendorf since 1602 but the main growth of Derendorf was in the time of Industrial Revolution.
Derendorf is traditionally an industrial area of Düsseldorf, inhabited mostly by a working-class population. The steelworks of Rheinmetall, the slaughterhouse and the brewery Schlösser are located here .
Many inhabitants of Derendorf are immigrants from Turkey, and the borough houses the central mosque of the Muslims in Düsseldorf.