Denice is a comune (municipality) in the Province of Alessandria in the Italian region Piedmont, located about southeast of Turin and about southwest of Alessandria. As of 30 June 2017, it had a population of 175 and an area of .
Denice borders the following municipalities: Mombaldone, Monastero Bormida, Montechiaro d'Acqui, Ponti, and Roccaverano.