ÃÂ<sup>6</sup>-Protoilludene synthase (EC 4.2.3.135, 6-protoilludene synthase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, ÃÂ<sup>6</sup>-protoilludene-forming). This enzyme catalyses the following chemical reaction
This enzyme is isolated from the fungus Armillaria gallica.