The deepwater grenadier (Coryphaenoides profundicolus) is a species of deep-sea fish in the family Macrouridae.
The deepwater grenadier is very large for its genus, measuring up to and . Olfaction and taste are important senses for finding prey, which is unsurprising as it lives in the near-total darkness of the deep sea. It has a swim bladder, showing that it is a mobile forager.
The deepwater grenadier lives in the Atlantic Ocean, off the Bay of Biscay and Canary Islands, and in the Great Australian Bight; it lives at depths of up to . The specific name is from Latin profundus ("deep") and the suffix -colus ("inhabitant"); -colus, -colum is not considered to be correct Latin but is still used in several species names. Otolith studies have shown that the deepwater grenadier lives at a variety of temperatures during its life.
It is parasitised by Lepidapedon zubchenkoi and Steringophorus thulini, both trematode worms of the order Plagiorchiida.