Deep Gut Run is a stream in the U.S. state of West Virginia.
Deep Gut Run has a sharply defined course, hence the original name Deep Cut Run.
According to the Geographic Names Information System, it has also been known historically as:
Deep Gut Run rises at New Manchester, in Hancock County and then flows southwest to join the Ohio River about north-northwest of New Cumberland.
Deep Gut Run drains of area, receives about of precipitation, has a wetness index of 324.93, and is about 59% forested.