Dargazin-e Sharqi Rural District () is in Shahanjarin District of Dargazin County, Hamadan province, Iran. Its capital is the village of Kaj, whose population at the time of the 2016 National Census was 1,053 in 334 households.
After the 2016 census, Qorveh-ye Darjazin District separated from Razan County in the establishment of Dargazin County, and Dargazin-e Sharqi Rural District was created in the new Shahanjarin District.