Daphnetin is a chemical compound with the molecular formula . It has been isolated from plants of the genus Daphne. It has also been found in Matricaria chamomilla (chamomile).
It a crystalline solid with a melting point of 256 ðC. It is soluble in boiling water.
Daphnetin can undergo enzymatic glycosylation to yield its 7-O-glucoside which is called daphnin (daphnetin 7-ò-<small>D</small>-glucopyranoside). The reaction is catalyzed by the enzyme O-dihydroxy coumarin 7-O-glucosyltransferase.
Daphnetin shows several neuroprotective and anti-inflammatory effects on the inhibition of the TLR4/NF-úB mediated inflammatory signaling pathway. They also could inhibit the IKKs/IkBa/NF-úB, AKT, and the Src/FAK/ERK1/2 multi-target medication signaling pathway for anti-angiogenesis and cancer.
Daphnetin has been reported to be a strong sensitizer, which means that this compound and its glycosidic derivatives (e.g. daphnin) can be a cause of allergic reactions.