The 2018 Danish Handball Cup (), known as Santander Cup 2018 for sponsorship reasons, is the 55th edition of the national women's handball cup tournament. Team Esbjerg are the defending champions.
The initial 6 rounds are managed by the regional federations with the DHF taking over the tournament at the round of 16. It ultimately results in a final four event between Christmas and New Year. The winner of the tournament qualify for the Super Cup where they meet the season's league winner. If the same team wins both the league and the cup, the losing cup finalist will be participating in the Super Cup.
The round of 32 ties were scheduled through March to May 2018.
|- !colspan="3" style="background:#ccccff;"| 27 March
|- !colspan="3" style="background:#ccccff;"| 10 April
|- !colspan="3" style="background:#ccccff;"| 11 April
|- !colspan="3" style="background:#ccccff;"| 12 April
|- !colspan="3" style="background:#ccccff;"| 17 April
|- !colspan="3" style="background:#ccccff;"| 25 April
|- !colspan="3" style="background:#ccccff;"| 1 May
|- !colspan="3" style="background:#ccccff;"| 2 May
|- !colspan="3" style="background:#ccccff;"| 3 May
|- !colspan="3" style="background:#ccccff;"| 5 May
|- !colspan="3" style="background:#ccccff;"| 14 May
|- !colspan="3" style="background:#ccccff;"| 15 May
|- !colspan="3" style="background:#ccccff;"| 17 May
The round of 16 ties were scheduled for 14âÂÂ23 August 2018.
|- !colspan="3" style="background:#ccccff;"| 14 August
|- !colspan="3" style="background:#ccccff;"| 22 August
|- !colspan="3" style="background:#ccccff;"| 23 August
|- !colspan="3" style="background:#ccccff;"| 24 August
The quarter-final ties were scheduled for 17âÂÂ20 September 2018.
|- !colspan="3" style="background:#ccccff;"| 17 September
|- !colspan="3" style="background:#ccccff;"| 18 September
|- !colspan="3" style="background:#ccccff;"| 20 September
The final four event is scheduled for 29âÂÂ30 December 2017 in Blue Water Dokken, Esbjerg.
Counted from the round of 16 when DHF took over the tournament.
MVP was announced after the final on 30 December 2018.