Daniels Run is a third-order tributary to Tenmile Creek in Washington County, Pennsylvania.
According to the Geographic Names Information System, it has also been known historically as:
Daniels Run rises about south of Glyde, Pennsylvania, and then flows south to join Tenmile Creek at West Zollarsville.
Daniels Run drains of area, receives about 40.3 in/year of precipitation, has a wetness index of 311.05 and is about 65% forested.