The Daniel and Nellie Byrns House is a historic house at 221 Mill Street in Lodi, Wisconsin.
The house was built in 1915 for local grocer Daniel Byrns and his wife Nellie. Both Daniel and Nellie were Irish immigrants; they originally lived on a farm in the Town of Lodi, but Byrns opened a grocery store in the city by 1913. The one-and-a-half-story house has a bungalow design, a popular choice in the 1910s; its architect and builder are unknown. The house features a screened wraparound porch, square pilasters flanking the front entrance, and a large gabled dormer with a small balcony above the entrance. It is the largest and best-preserved example of a bungalow in Lodi.
The house was added to the National Register of Historic Places in 2008.