Damon Run is a long 2nd order tributary to Brokenstraw Creek. It is classed as a cold-water fishery by the Pennsylvania Fish and Boat Commission.
Damon Run rises on the divide between it and Prosser Run in Warren County, Pennsylvania about 1 mile southeast of Baker Hill and flows southeast to meet Brokenstraw Creek about 1.5 miles northwest of Spring Creek, Pennsylvania.
Damon Run drains of the Pennsylvania High Plateau province and the northwestern glaciated plateau and is underlaid by the Venango Formation. The watershed receives an average of 45.8 in/year of precipitation and has a wetness index of 393.52. The watershed is about 62% forested.