DMT-d4, or D<sub>4</sub>DMT, also known as ñ,ñ,ò,ò-tetradeutero-DMT, is a serotonin receptor modulator and putative psychedelic drug of the tryptamine family related to dimethyltryptamine (DMT). It is the isotopologue of DMT in which the hydrogen atoms at the ñ and ò positions have been replaced with the deuterium isotopes.
DMT-d4 is thought to be resistant to metabolism by monoamine oxidase (MAO) compared to DMT. Relatedly, D<sub>4</sub>DMT, at the same dose, shows stronger effects, 2- to 3-fold higher brain levels, a longer duration, and a faster onset than DMT in rodents. In addition, DMT-d4, unlike DMT, might be orally active, though this remains to be studied. D<sub>4</sub>DMT was said to have similar properties to the combination of DMT with a monoamine oxidase inhibitor (MAOI) in rodents. The metabolism and metabolites of DMT-d4 have been studied.
The chemical synthesis of DMT-d4 has been described.
A notable analogue of DMT-d4 is 5-MeO-DMT-d4. Other analogues of DMT-d4 include deuterated forms of tryptamine like ñ,ñ-dideuterotryptamine and ò,ò-dideuterotryptamine.
DMT-d4 was first described in the scientific literature by 1982.