DENN domain-containing protein 1B is a protein encoded by DENND1B human gene, located on chromosome 1.
The protein has tripartite DENN domain at N-terminal.
The protein is a guanine nucleotide exchange factor for RAB35.
The gene is hypothesized by Danish scientists Klaus Bønnelykke and Hans Bisgaard to be related to asthma. The gene may affect susceptibility to chronic cavitary pulmonary aspergillosis. Variants of this gene are also associated with obesity in both humans and dogs.