DCW234

DCW234, also known as butyl 4-(butyryloxy)benzoate, is a synthetic nonsteroidal estrogen and a selective agonist of the ERβ. It shows modest selectivity in terms of affinity and transactivation for the ERβ over the ERα. Its affinity for the ERβ was 3.43 ÃŽÂ¼M and for the ERα was 22.5 ÃŽÂ¼M, while it activated the ERβ and ERα with EC₅₀ values of 1.71–2.5 ÃŽÂ¼M and 19.8–22.5 ÃŽÂ¼M, respectively. As such, its binding selectivity for the ERβ over the ERα was 7-fold and its functional selectivity for the ERβ over the ERα was between 10- and 13-fold.

See also

• Diarylpropionitrile

References