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D-serine ammonia-lyase

The enzyme <small>D</small>-serine ammonia-lyase (EC 4.3.1.18), with systematic name <small>D</small>-serine ammonia-lyase (pyruvate-forming), catalyzes the chemical reaction

<small>D</small>-serine = pyruvate + NH<sub>3</sub> (overall reaction)
:(1a) <small>D</small>-serine = 2-aminoprop-2-enoate + H<sub>2</sub>O
:(1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous)
:(1c) 2-iminopropanoate + H<sub>2</sub>O = pyruvate + NH<sub>3</sub> (spontaneous

Other names in common use include <small>D</small>-hydroxyaminoacid dehydratase, <small>D</small>-serine dehydrase, <small>D</small>-hydroxy amino acid dehydratase, <small>D</small>-serine hydrolase, <small>D</small>-serine dehydratase (deaminating), <small>D</small>-serine deaminase, and <small>D</small>-serine hydro-lyase (deaminating). This enzyme participates in glycine, serine and threonine metabolism. It employs one cofactor, pyridoxal phosphate.

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