In enzymology, a D-arabinose 1-dehydrogenase [NAD(P)<sup>+</sup>] () is an enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are D-arabinose, NAD<sup>+</sup>, and NADP<sup>+</sup>, whereas its 4 products are D-arabinono-1,4-lactone, NADH, NADPH, and H<sup>+</sup>.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is D-arabinose:NAD(P)<sup>+</sup> 1-oxidoreductase. This enzyme is also called D-arabinose 1-dehydrogenase [NAD(P)<sup>+</sup>].
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .