-Deprenyl, also known as or dextro-N-propargyl-N-methylamphetamine, is an MAO-B inhibitor that metabolizes into -amphetamine and -methamphetamine and is therefore also a norepinephrineâÂÂdopamine releasing agent. It is one of the two enantiomers of deprenyl and is the opposite enantiomer of -deprenyl (selegiline).
-Deprenyl, also an MAO-B inhibitor, metabolizes to -amphetamine and -methamphetamine, which are both norepinephrine releasing agents. In contrast, -deprenyl additionally has dopaminergic effects and has been found to be reinforcing in scientific research, whereas -deprenyl is not known to have any appreciable psychological reinforcement.Selegiline is also a more potent MAO-B inhibitor than D-Deprenyl and is the main motivator for its selection for the medical market.
In addition to its actions as an MAO-B inhibitor and NDRA, -deprenyl has been found to bind with high affinity to sigma receptors (K<sub>i</sub> = 79âÂÂ1,800nM) similarly to various other amphetamine derivatives. Its -isomer, selegiline, binds with several-fold lower affinity in comparison.