Cuttalosa Creek is a tributary of the Delaware River in Bucks County, Pennsylvania.
Cuttalosa Creek rises from two springs just over a mile to the west of the village of Solebury in Solebury Township at an elevation of and is oriented to the northeast, then turns north, then northeast, then north until it reaches its confluence with the Delaware at Cuttalossa (Lumberton) about a mile upstream of Hendricks Island at an elevation of . Cuttalosa Road crosses over the stream five times.
The name Cuttalosa was derived from the Lenape name Quatalossi for their village nearby.
Cuttalosa Creek lies on the Stockton Formation, a layer of bedrock consisting of light-gray to light brown sandstone, siltstone, and mudstone, laid down in the Late Triassic.
At one time, the Lenape occupied a village in the valley. Later, there were several mills along the creek. One was built by Samuel Armitage in 1752 which operated until his descendant, Amos Armitage, closed the mill in 1929.