Cruzille is a commune in the Saône-et-Loire department in the region of Bourgogne-Franche-Comté in eastern France.
Besides the town proper, Cruzille is also composed of five hamlets : Collonge, Sagy-le-Haut and Sagy-le-bas, located in the winegrowing valley in the east, and Fragnes and Ouxy, in the west, on the other side of the Bois de la Montagne. Both Fragnes and Ouxy are remarquable by the fact they are turned towards the Cormation valley at the border between the winegrowing valley of the Haut-Mâconnais and the more cattle farming oriented valley of Cluny.
Cruzille is a wine-producing village in the area of production of Mâcon-Lugny with the three villages of Lugny, Saint-Gengoux-de-Scissé and Bissy-la-Mâconnaise. Most vineyards are composed of chardonnay which is almost exclusively vinified at the Cave de Lugny. There are however several independent winemakers in the village such Domaine des Vignes du Maynes and Domain Guillot-Broux (which was a pioneer in organic wines in France starting back in 1954).
There is a national forest (La forêt des Grisons) composed of deciduous trees and conifers in the village.
The inhabitants are called Cruzillois. There are around 200 inhabitants.
There are no more schools in the village. There is a nursery in the old school building. Older children can go to primary school to Lugny or Saint-Gengoux-de-Scissé. There is a secondary school in Lugny. For lycées, teenagers should go to high school to Tournus but some also decide to go one in Mâcon.
Cruzille is part the Notre-Dame-des-Coteaux en Mâconnais parish based in the nearby village of Lugny.
Cruzille's economy is mostly in the wine-making industry.