Cross Creek is a long 4th order tributary to the Ohio River in Brooke County, West Virginia.
Cross Creek rises about 1.5 miles northeast of Buffalo, Pennsylvania, in Washington County and then flows northwesterly into West Virginia and Brooke County to join the Ohio River about 1 mile south of Follansbee, West Virginia.
Cross Creek drains of area, receives about 40.1 in/year of precipitation, has a wetness index of 332.83, and is about 59% forested.