Crespina Lorenzana is a comune (municipality) in the Province of Pisa in the Italian region Tuscany.
Crespina Lorenzana borders the following municipalities: Casciana Terme Lari, Cascina, Collesalvetti, Fauglia, Orciano Pisano, Santa Luce.
The municipality is composed by six frazioni (towns and villages):
The municipality of Crespina Lorenzana was created on 1 January 2014 by merging the former municipalities of Crespina and Lorenzana. The municipal seat is in Crespina.