Costigliole d'Asti () is a small Italian town in the Province of Asti, southern Piedmont. It lies about south of the city of Asti in the Alto Monferrato, on the edge of the Langhe, in the alluvial plain of the river Tanaro southwards into the hills. The name derives from the Latin .
The neighbouring communes are Agliano Terme, Antignano, Calosso, Castagnole delle Lanze, Isola d'Asti, Montegrosso d'Asti, and San Martino Alfieri (in the Province of Asti); and Castiglione Tinella and Govone (in the Province of Cuneo).
The imposing, well-preserved medieval Gothic style castle dating from the 11th century is the town's defining feature. In the conflict between the Guelphs and Ghibellines the castle was much contested between the two factions. The Counts of Verasis Asinara inherited the castle in the 17th century. It was the home of the notorious Virginia Oldoini, wife of Francesco Verasis, Count of Castiglione; the castle having been part of his inheritance. It has been renovated a number of times over the centuries.
Costigliole d'Asti is particularly known for its viticulture. Its vineyards, which cover an area of more than , are the most extensive of any Piedmontese commune.
The main grape varieties grown are Barbera, Dolcetto, Grignolino, Freisa and Brachetto. The Denominazione di Origine Controllata (DOC) wines produced from these are:
The Moscato Bianco grape is grown for the production of three Denominazione di Origine Controllata e Garantita (DOCG) or DOC wines:
The Cortese and Chardonnay varieties are used for two DOC wines: