Corn Creek is an unincorporated community and census-designated place in Mellette County, South Dakota, United States. Its population was 113 as of the 2020 census. The community is located near the intersection of South Dakota Highway 44 and South Dakota Highway 63.
According to the United States Census Bureau, the community has an area of ; of its area is land, and is water.
The community is served by White River School District .