The 2016 Copa Sudamericana () was the 15th edition of the Copa Sudamericana, South America's secondary club football tournament organized by CONMEBOL.
The finals were originally to be played between Brazilian team Chapecoense and Colombian team Atlético Nacional. However, on 28 November 2016, LaMia Flight 2933, which was carrying Chapecoense squad to the first leg, crashed on the way to the José MarÃÂa Córdova International Airport. There were 71 fatalities, including 19 of the 22 Chapecoense players on the plane. CONMEBOL immediately suspended all activities, including the scheduled final matches, in the early morning of 29 November. In light of these events, Atlético Nacional requested that CONMEBOL award the title to Chapecoense, which they did on 5 December, while Atlético Nacional received the "CONMEBOL Centenario Fair Play" award for their gesture.
As winners of the 2016 Copa Sudamericana, Chapecoense earned the right to play against the winners of the 2016 Copa Libertadores in the 2017 Recopa Sudamericana, and the winners of the 2016 J.League Cup in the 2017 Suruga Bank Championship. They also automatically qualified for the 2017 Copa Libertadores group stage. Santa Fe were the defending champions, but were eliminated by Cerro Porteño in the Round of 16.
The following 47 teams from the 10 CONMEBOL associations qualified for the tournament:
The entry stage is determined as follows:
The schedule of the competition was as follows (all dates listed are Wednesdays, but matches may be played on Tuesdays and Thursdays as well).