Cooper Creek is a stream in Henry and St. Clair counties of Missouri. It is a tributary of Deepwater Creek within the Truman Reservoir.
The stream headwaters are in St Clair County just west of the community of Ohio at . The stream flows to the northeast into Henry County and passes under Missouri Route 13. The confluence with the Deepwater Creek arm of the Truman Reservoir is at approximately midway between Deepwater to the northwest and Brownington to the southeast.
Cooper Creek bears the name of a pioneer citizen.