Coon Creek is a stream in Miller County in the U.S. state of Missouri. It is a tributary of the Osage River.
The stream headwaters arise along the south side of Missouri Route A about one mile east of that roads intersection with Missouri Route 17. The stream flows northeast passing under Route A then turns north-northwest to pass under Missouri Route 52 and enters the Osage about three miles northeast (downstream) of Tuscumbia.
The headwaters are at: and an elevation of about . The confluence with the Osage is at: at an elevation of .
Coon Creek was so named due to the presence of raccoons near its course.